Rivaroxaban Impurity 12 synthesis
- Product Name:Rivaroxaban Impurity 12
- CAS Number:936232-22-3
- Molecular formula:C17H18ClN3O4S
- Molecular Weight:395.86
![2-Thiophenecarboxamide, N-[[(5S)-3-(4-aminophenyl)-2-oxo-5-oxazolidinyl]methyl]-5-chloro-](/CAS/20210305/GIF/482308-02-1.gif)
Yield:936232-22-3 62 g
Reaction Conditions:
in ethanol at 60;Solvent;Temperature;
Steps:
1.6; 2.6; 3.6; 4.6
(6) 400ml of ethanol was added to a 1L reaction flask, 58g of intermediate V was added, 8g of ethylene oxide was added dropwise, and the addition was completedAfter that, the reaction was kept at 60C, and HPLC was controlled and followed.After the reaction is complete, concentrate to dryness to obtain 62g of intermediate VI, which goes directly to the next reaction.
References:
CN112159402,2021,A Location in patent:Paragraph 0007; 0023; 0028; 0029; 0034; 0035; 0039; 0041
![2-Thiophenecarboxamide, 5-chloro-N-[[(5S)-3-[4-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]phenyl]-2-oxo-5-oxazolidinyl]methyl]-](/CAS/20210305/GIF/936232-12-1.gif)
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