ChemicalBook CAS DataBase List REMIFENTANIL

REMIFENTANIL synthesis

5synthesis methods

Product Name:REMIFENTANIL
CAS Number:132875-61-7
Molecular formula:C20H28N2O5
Molecular Weight:376.45

132539-07-2 Synthesis

132539-07-2
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Yield:132875-61-7 60%

Reaction Conditions:

with potassium carbonate in water;toluene; pH=9Purification / work up;

Steps:

5 Example 5
This solid is the dissolved in water (130 ml), then toluene (75 ml) is added and the mixture basified with a 25% potassium carbonate solution to pH =9. The layers are separated and the aqueous layer is extracted twice with toluene (60 ml). The combined organic layers are dried over anhydrous sodium sulphate, filtered and concentrated under vacuum to yield 3-[4-methoxycarbonyl-4-[(1-oxopropyl)phenylamino)]-1-piperidine]propanoic acid methyl ester (11.21 g, 60%) as an oil.

References:

KERN PHARMA, S.L. EP1867635, 2007, A1 Location in patent:Page/Page column 10

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