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ChemicalBook CAS DataBase List RARECHEM AL BI 0374
103858-54-4

RARECHEM AL BI 0374 synthesis

3synthesis methods
-

Yield:103858-54-4 58%

Reaction Conditions:

Stage #1: 5-bromo-1H-indole;trifluoroacetyl chloridewith pyridine in tetrahydrofuran at 0 - 20; for 17 h;Inert atmosphere;
Stage #2: ethanolwith potassium hydroxide in water at 20; for 6 h;Reflux;

References:

Cao, Trung;Deitch, Joshua;Linton, Elizabeth C.;Kozlowski, Marisa C. [Angewandte Chemie - International Edition,2012,vol. 51,# 10,p. 2448 - 2451] Location in patent:supporting information; experimental part

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