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ChemicalBook CAS DataBase List (R,R)-Hydroxy Bupropion
192374-15-5

(R,R)-Hydroxy Bupropion synthesis

3synthesis methods
34841-35-5 Synthesis
3'-Chloropropiophenone

34841-35-5
479 suppliers
$5.00/5g

-

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: LDA / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / -78 °C
2.1: 82 percent / AD-mix-α; H2O / 2-methyl-propan-2-ol
3.1: lutidine / CH2Cl2 / -40 °C
4.1: CH2Cl2 / -40 °C

References:

Fang, Qun K.;Han, Zhengxu;Grover, Paul;Kessler, Donald;Senanayake, Chris H.;Wald, Stephen A. [Tetrahedron Asymmetry,2000,vol. 11,# 18,p. 3659 - 3663]

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