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ChemicalBook CAS DataBase List (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol
22348-32-9

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol synthesis

7synthesis methods
Draw 14 kg of tetrahydrofuran into the reaction kettle. 61.5 kg of a 34% strength solution of phenylmagnesium chloride in tetrahydrofuran was added to the reaction vessel to initiate agitation and cooling cycles. The control temperature is 10 to 60 °C. The dropping time was controlled for 5 to 6 hours, and stirring was continued for 1 hour. Pump 24 kg of concentrated hydrochloric acid (mass concentration 36%) into the matching drip tank of the reaction kettle. constantly dropping, the dropping time is controlled for 1 hour, and the dropping process control temperature does not exceed 45 ° C. After the addition was completed, stirring was continued for 8 hours.Cool down to -5 ° C ~ 5 ° C to obtain (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol, a total of 17.2 kg, yield 85%.
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Yield:22348-32-9 100%

Reaction Conditions:

with sodium hydroxide in ethanol; for 2.5 h;Reflux;

References:

Nikolic, Nikola A.;Beak, Peter [Organic Syntheses,1997,vol. 74,p. 23 - 23]

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