ChemicalBook CAS DataBase List (R)-3-Methylmorpholine

(R)-3-Methylmorpholine synthesis

8synthesis methods

Product Name:(R)-3-Methylmorpholine
CAS Number:74572-04-6
Molecular formula:C5H11NO
Molecular Weight:101.15

119844-67-6
47 suppliers
$90.00/50mg

74572-04-6
174 suppliers
$10.00/250mg

Yield:74572-04-6 75%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at 0 - 20; for 16 h;

Steps:

General Procedure for synthesis of 5:
General procedure: LAH (2 equiv.) in THF (100 mL) was cooled to 0oC inan ice bath under nitrogen. A solution of 4 (1 equiv.) in THF (20 mL) was added dropwise, and the resulting solution was stirred at RT for 16 hrs. The reaction mixture was cooled to 0oC andcarefully quenched with water (2 mL), 2 N NaOH (2 mL) and water (8 mL). The resulting slurrywas stirred at RT for 1 h and filtered through Celite. The filter cake was washed with ethylacetate and discarded. The filtrate was dried (Na2SO4), separated and concentrated to afford 5 asa colorless oil.

References:

Dugar, Sundeep;Sharma, Amit;Kuila, Bilash;Mahajan, Dinesh;Dwivedi, Sandeep;Tripathi, Vinayak [Synthesis,2014,vol. 46,art. no. 46] Location in patent:supporting information

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74571-98-5 Synthesis