ChemicalBook CAS DataBase List QUINOXYFEN

QUINOXYFEN synthesis

4synthesis methods

Product Name:QUINOXYFEN
CAS Number:124495-18-7
Molecular formula:C15H8Cl2FNO
Molecular Weight:308.13

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124495-18-7
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Yield:124495-18-7 96%

Reaction Conditions:

in N,N-dimethyl-formamide at 50 - 80; for 6 h;Temperature;

Steps:

6

Then the N,N-dimethylformamide (DMF) suspension was cooled to 50 ° C, and 61 g of 4,5,7-trichloroquinoline was added to raise the temperature.The reaction was carried out at 80 ° C for 6 hours, and then DMF was recovered under a negative pressure of -0.087 MPa for 1.7 hours. After the completion of the recovery of DMF, 100 g of water and toluene recovered under normal pressure in step 7 were added, and the temperature was once at 95 ° C at 30 ° C. After stirring for 1 hour, and then standing at this temperature for 10 minutes, the lower layer of water was separated, and toluene was recovered under normal pressure. After the recovery, 300 g of 99% methanol was added to recrystallize and the temperature was raised to 64 ° C, and the temperature was 95 rpm. Stir for 30 minutes, cool down to below 20 ° C for 10 hours, at 75 ° CAfter drying for 4 hours, phenoxyquinoline was obtained. Among them, the weight of phenoxyquinoline was 72 g, and the yield was 96%; and the formula for synthesizing phenoxyquinoline of 4,5,7-trichloroquinoline was as shown in the formula (7).

References:

CN108689927,2018,A Location in patent:Paragraph 0061-0062; 0075-0076; 0077-0078; 0084; 0085-0086

371-41-5 Synthesis