Quinoxaline, 6-iodo- (9CI) synthesis
- Product Name:Quinoxaline, 6-iodo- (9CI)
- CAS Number:50998-18-0
- Molecular formula:C8H5IN2
- Molecular Weight:256.04
131543-46-9
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21304-38-1
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$36.00/250mg
50998-18-0
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$69.00/100mg
Yield:50998-18-0 64%
Reaction Conditions:
with acetic acid in ethanol;water at 100;
Steps:
71.a
A solution of 4-iodo-benzene-l,2-diamJne (0.46g, 1.96mmol), ethanedial [40% in water] (2.25mL), acetic acid (ImL) and ethanol (2OmL) were heated to 1000C for several hours and then cooled to room temperature. Water was added and the crude product was extracted with ethyl acetate. The product was purified via silica gel column chromatography with hexane: ethyl acetate (1:1) to give 0.323g (64%) of 6- iodo-quinoxaline. 1H NMR (400 MHz, CDCl3) S 8.77 (dd, 2H, J=2.0, 8.8Hz), 8.46 (d, IH, 2.0Hz), 7.96 (dd, IH, J=2.0, 8.8Hz), 7.75 (d, IH, J=8.8Hz).
References:
WO2007/75567,2007,A1 Location in patent:Page/Page column 131
21304-38-1
104 suppliers
$36.00/250mg
517-21-5
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$17.00/25g
50998-18-0
53 suppliers
$69.00/100mg