ChemicalBook CAS DataBase List Pyrimidine, 5-chloro-4-methyl-

Pyrimidine, 5-chloro-4-methyl- synthesis

3synthesis methods

Product Name:Pyrimidine, 5-chloro-4-methyl-
CAS Number:54198-82-2
Molecular formula:C5H5ClN2
Molecular Weight:128.56

Pyrimidine, 5-chloro-4,5-dihydro-4-methyl-

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54198-82-2
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Yield:-

Reaction Conditions:

with 2,3-dicyano-5,6-dichloro-p-benzoquinone in tetrahydrofuran at 0; for 6 h;

Steps:

22.b (b) 5-chloro-4-methylpyrimidine
To a solution of 5-chloro-4-methyl-4,5-dihydropyrimidine (2 g) in THF (30 mL) was added DDQ (1 g) dropwise at 0 °C and the resulting mixture was stirred for 6 hours. After the 5- chloro-4-methyl-4,5-dihydropyrimidine was consumed completely as shown by TLC, water (30 mL) was added and the mixture was extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine and dried over anhydrous Na₂S0₄. After filtration and concentration, the crude product was purified by column chromatography to give the title compound.

References:

SUNOVION PHARMACEUTICALS INC.;CAMPBELL, John, Emmerson;CAMPBELL, Una;HANANIA, Taleen, G.;SHAO, Liming WO2013/119895, 2013, A1 Location in patent:Paragraph 00297

83942-10-3 Synthesis