Pyrimidine, 4-chloro-5,6-dimethyl- (7CI,9CI) synthesis
- Product Name:Pyrimidine, 4-chloro-5,6-dimethyl- (7CI,9CI)
- CAS Number:67434-65-5
- Molecular formula:C6H7ClN2
- Molecular Weight:142.59
4316-97-6
204 suppliers
$8.00/1g
13061-96-6
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$6.00/1g
67434-65-5
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$83.00/100mg
Yield:67434-65-5 41%
Reaction Conditions:
with caesium carbonate;tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide;toluene at 140; for 1 h;Irradiation;
Steps:
8
To a mixture of 4,6-dichloro-5-methylpyrimidine (available from Sigma- Aldrich No.595446) (0.50 g, 3.07 mmol) and tetrakis(triphenylphosphine)palladium (0) (0.18 g, 0.15 mmol) in toluene (6 ml) and DMF (1 ml) was added cesium carbonate (3 g, 9.20 mmol), followed by methylboronic acid (0.20 g, 3.37 mmol). The resulting reaction mixture was heated at 140 0C under microwave irradiation (2 cycles x 30 min), allowed to cool down to room temperature and filtered. Solvents were removed under reduced pressure. The residue was taken-up in EtOAc and washed with a saturated NaHCO3 aqueous solution and brine. The organic phase was separated, dried (Na2SO4), filtered and concentrated to afford the title compound D8 (0.18 g, 1.26 mmol, 41% yield). UPLC: rt = 0.53 min, peak observed: 143
References:
WO2009/3997,2009,A1 Location in patent:Page/Page column 20-21
34916-78-4
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67434-65-5
43 suppliers
$83.00/100mg
34916-78-4
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$45.00/50mg
67434-65-5
43 suppliers
$83.00/100mg
28456-54-4
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$48.00/500mg
67434-65-5
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$83.00/100mg
609-14-3
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$5.00/5g
67434-65-5
43 suppliers
$83.00/100mg