ChemicalBook CAS DataBase List Pyridine, 4-(difluoromethyl)- (9CI)

Pyridine, 4-(difluoromethyl)- (9CI) synthesis

6synthesis methods

Product Name:Pyridine, 4-(difluoromethyl)- (9CI)
CAS Number:82878-62-4
Molecular formula:C6H5F2N
Molecular Weight:129.11

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Yield: 54 %Spectr.

Reaction Conditions:

Stage #1:4-bromopyridine hydrochloride with tris-(trimethylsilyl)silane;[4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate;sodium carbonate;4,4'-di-tert-butyl-2,2'-bipyridine in 1,2-dimethoxyethane for 0.25 h;Inert atmosphere;
Stage #2:bromodifluoromethane in 1,2-dimethoxyethane at 30; for 18 h;Sealed tube;Irradiation;Inert atmosphere;

References:

Bacauanu, Vlad;Cardinal, Sébastien;Yamauchi, Motoshi;Kondo, Masaru;Fernández, David F.;Remy, Richard;MacMillan, David W. C. [Angewandte Chemie - International Edition,2018,vol. 57,# 38,p. 12543 - 12548][Angew. Chem.,2018,vol. 130,p. 12723 - 12728,6] Location in patent:supporting information