PROPARGYL BENZENESULFONATE synthesis
- Product Name:PROPARGYL BENZENESULFONATE
- CAS Number:6165-75-9
- Molecular formula:C9H8O3S
- Molecular Weight:196.22
Yield:6165-75-9 96%
Reaction Conditions:
with sodium hydroxide in water at 0; for 10 h;Large scale;Green chemistry;Reagent/catalyst;Temperature;
Steps:
1-5 Example 5:
Add 500 kg of benzenesulfonyl chloride, 40 kg of propargyl alcohol and 150 kg of water to a 500 liter reactor, turn on the cooling device, control the temperature at 0 ° C, add 90 kg of 32% aqueous sodium hydroxide solution within 8 hours; The reaction was further stirred at 0 ° C for 2 hours. The reaction of the benzenesulfonyl chloride in the gas phase detection system was completed, and the mixture was statically separated. The organic phase was washed with 2×50 kg of brine, dried over anhydrous sodium sulfate and distilled under reduced pressure to collect 142-148 ° C / The 4 mmHg fraction obtained 128 kg of propargyl benzenesulfonate in a yield of 96% and a gas phase purity of 99.5%
References:
CN109456235,2019,A Location in patent:Paragraph 0019-0023
