ChemicalBook CAS DataBase List PHENOTHIAZINE-10-ACETIC ACID

PHENOTHIAZINE-10-ACETIC ACID synthesis

7synthesis methods

Product Name:PHENOTHIAZINE-10-ACETIC ACID
CAS Number:25244-68-2
Molecular formula:C14H11NO2S
Molecular Weight:257.31

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Yield:25244-68-2 96%

Reaction Conditions:

with triethylamine in N,N-dimethyl-formamide at 60; pH=8.7;Temperature;pH-value;

Steps:

1-4 Example 3:

1) Add 0.006 mol of phenothiazine to a 250 mL three-necked flask.0.0072 mol of potassium chloroacetate, 0.084 mol of N,N-dimethylformamide;2) Heat the flask and add triethylamine to the solution to adjust the pH to 8.7.Heated to 60 ° C with TLC monitoring,And the developing agent used in the TLC monitoring is a solution in which ethyl acetate and petroleum ether are mixed in a volume ratio of 1:3;3) After the end of the reaction, the three-necked flask was cooled to room temperature.After adding dropwise concentrated HCl, the pH of the solution in the flask was adjusted to 2.8;4) Pour the solution obtained in step 3) into water,After the white solid is precipitated, it is suction filtered, rinsed and dried;5) recrystallizing the dried product using an anhydrous ethanol solution,Finally, N-carboxymethylphenothiazine is obtained. The yield was calculated and calculated to be 96%, m.p: 69-72 °C.

References:

CN104031004,2016,B Location in patent:Paragraph 0032-0060

68825-29-6 Synthesis