Phenolphthalein synthesis
- Product Name:Phenolphthalein
- CAS Number:77-09-8
- Molecular formula:C20H14O4
- Molecular Weight:318.32
Yield:77-09-8 90%
Reaction Conditions:
with mixed metal catalyst derived from Thlaspi at 80; for 0.0833333 h;Friedel-Crafts Acylation;
Steps:
3.3.1.3.1.2 Phenolphthalein
500 mg of phthalic anhydride, 500 mg of phenol and 1 g of crude catalyst derived from Thlaspi (Example 1.1, 12N HCl) dehydrated at 110° C. for a few minutes are placed in a single-necked flask and heated at 80° C. for 5 minutes. (0510) After cooling down, the reaction mixture is diluted in 5 mL of a water/ethanol mixture. 1 mL of solution is taken then added to a 3M soda solution. (0511) In the case of phenolphthalein, the solution becomes pink immediately. (0512) After washing with ether, the phenolphthalein crystallizes easily.
References:
US9149796,2015,B2 Location in patent:Page/Page column 41
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