Phenol, 2-nitro-4-(1-pyrrolidinylsulfonyl)- synthesis
- Product Name:Phenol, 2-nitro-4-(1-pyrrolidinylsulfonyl)-
- CAS Number:722464-31-5
- Molecular formula:C10H12N2O5S
- Molecular Weight:272.28
![1-[(4-methoxy-3-nitrophenyl)sulfonyl]pyrrolidine](/CAS/20180601/GIF/823823-46-7.gif)
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Yield:-
Reaction Conditions:
Stage #1: 1-(4-methoxy-3-nitrobenzenesulfonyl)pyrrolidinewith potassium hydroxide;water in dimethyl sulfoxide at 0 - 80; for 6 h;
Stage #2: with hydrogenchloride in water;dimethyl sulfoxide;
Steps:
33.3 Production of 1-(4-methoxy-3-nitrobenzenesulfonyl)pyrrolidine
Step 3 Production of 2-nitro-4-(pyrrolidine-1-sulfonyl)phenol 1-(4-Methoxy-3-nitrobenzenesulfonyl)pyrrolidine (2.054 g) was dissolved in dimethyl sulfoxide (40 mL), and 50% aqueous potassium hydroxide (40 mL) was added under ice-cooling. After stirring with heating at 80° C. for 6 hrs, the mixture was ice-cooled, and 6N hydrochloric acid (80 mL) was added. The mixture was extracted with chloroform. The extract was washed successively with water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated to give the title compound (2.198 g) as a yellow solid.
References:
US2007/10670,2007,A1 Location in patent:Page/Page column 91
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