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ChemicalBook CAS DataBase List PENTA-L-PHENYLALANINE ACETATE SALT
65757-10-0

PENTA-L-PHENYLALANINE ACETATE SALT synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 9 steps
1.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 0 °C
1.2: 0.08 h / 0 °C
1.3: 24 h / 0 - 20 °C
2.1: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 20 °C / Inert atmosphere
3.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 0 °C
3.2: 0.08 h / 0 °C
3.3: 24 h / 0 - 20 °C
4.1: palladium 10% on activated carbon; hydrogen / ethanol / 2 h
5.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 0 °C
5.2: 0.08 h / 0 °C
5.3: 24 h / 0 - 20 °C
6.1: palladium 10% on activated carbon; hydrogen / ethanol / 2 h
7.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 0 °C
7.2: 0.08 h / 0 °C
7.3: 24 h / 0 - 20 °C
8.1: palladium 10% on activated carbon; hydrogen / ethanol / 2 h
9.1: lithium hydroxide monohydrate / methanol; water / 2 h / 20 °C

References:

Cindro, Nikola;Horvat, Gordan;Rinkovec, Tamara;Riva, Davide;Speranza, Giovanna;Tomi?i?, Vladislav;Vidovi?, Nikolina [Organic Letters,2020]