ChemicalBook CAS DataBase List Paroxetine Impurity 35

Paroxetine Impurity 35 synthesis

8synthesis methods

Product Name:Paroxetine Impurity 35
CAS Number:33842-14-7
Molecular formula:C9H8O3
Molecular Weight:164.16

369363-94-0
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33842-14-7
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Yield:33842-14-7 95%

Reaction Conditions:

with silver(I) tetrakis(3,5-bis(trifluoromethyl)phenyl)borate;water at 80; for 6 h;Green chemistry;chemoselective reaction;

Steps:

Optimization Studies with Silver Salts.

General procedure: Calculated amount of Ag salt (97.1 mg, 0.1 mmol) was weighed into a long necked glass vessel, followed by addition of alkyne (1 mmol). Internal standard n-dodecane (1mmol) and 3 mL water was then added. The whole set-up was placed in an oil bath at 80°C, stirred and heated for 12/24 hours. After completion of the reaction,3 mL EtOAc was added to it, stirred for 5 minutes and the organic layer was collected. The organic layer was passed through a very short column of silica to remove any impurities and subjected to GC-MS analysis.

References:

Saha, Sayantani;Sarbajna, Abir;Bera, Jitendra K. [Tetrahedron Letters,2014,vol. 55,# 8,p. 1444 - 1447] Location in patent:supporting information