Paliperidone Impurity 4 synthesis
- Product Name:Paliperidone Impurity 4
- CAS Number:152542-03-5
- Molecular formula:C23H28FN3O4
- Molecular Weight:429.48
16867-03-1
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Yield:-
Steps:
Multi-step reaction with 4 steps
1.1: trichlorophosphate / 1 h / 30 - 35 °C
1.2: 24 h / 35 - 40 °C
2.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 50 - 55 °C / Inert atmosphere
2.2: Inert atmosphere
2.3: 2 h / 5 - 85 °C
3.1: sodium carbonate / methanol / 70 - 75 °C / Inert atmosphere; Pressure vessel
4.1: hydrogen; sodium hydroxide / palladium 10% on activated carbon / water; methanol / 2 h / 25 - 35 °C / Inert atmosphere
4.2: pH 2.5 - 3
4.3: 0.5 h / 25 - 30 °C / pH 5 - 5.5
References:
ACTAVIS GROUP PTC EHF;DIXIT, Girish;KHILE, Anil, Shahaji;PATEL, Jayesh, Laljibhai;PRADHAN, Nitin, Sharadchandra WO2011/30224, 2011, A2
144598-75-4
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517-23-7
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