ChemicalBook CAS DataBase List p-Toluoyl chloride

p-Toluoyl chloride synthesis

12synthesis methods

Product Name:p-Toluoyl chloride
CAS Number:874-60-2
Molecular formula:C8H7ClO
Molecular Weight:154.59

99-94-5 Synthesis

99-94-5
576 suppliers
$9.00/1g

874-60-2
400 suppliers
$10.00/5g

Yield:874-60-2 100%

Reaction Conditions:

with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 35; for 1 h;

Steps:

Syntheses of Aryl Acid Chlorides (4a-f)
General procedure: The reaction scheme for the syntheses of aryl acid chlorides (4a-f) is shown in Scheme (1). Into a 250 mL two neck round bottomed flask equipped with a mechanical stirrer and a dropping funnel was placed in a thermostat bath. To a stirred solution of aryl acid (3a-f) 8 mM (3a: 0.98 g; 3b: 1.22g; 3c: 1.09 g; 3d: 1.34 g; 3e: 1.34 g; 3f: 1.18 g) in 100 mL CH₂Cl₂ at room temperature was added 16 mM (2.02 g) oxalyl chloride, 2 drops of DMF and the mixture was stirred at room temperature for 1h. The resulting mixture was concentrated under reduced pressure to afford acid chloride quantitatively and stored in air tight flask.

References:

Patel, Chirag Bhupendra;Dhaduk, Bhavin Babu;Parsania, Parsotam Hari [Letters in drug design and discovery,2015,vol. 12,# 6,p. 505 - 511]

FullText

13756-42-8 Synthesis