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6282-37-7

p-methyl-alpha-propylbenzyl alcohol synthesis

6synthesis methods
-

Yield:6282-37-7 100%

Reaction Conditions:

in diethyl ether at 0; for 0.5 h;

Steps:

2

j'006061 Io a solution of C3H7MgCl C2 M1 50 mmι>i) in ether (25 ml.) at 0 CC was added bcBzadehyde { 5 nil., 42.5 truxiol) in ether ( 50 nil..). The re&ultant sohition was suited at 0 3C for 30 minutes. The reaction was then quenched wish saturated NIi+Cl and diluted with ether. The organic layer was separated and washed successively with H;Q and brine, then dried over anliydroas Na^SO4, filtered, and concentrated in vacuo to afford the crude product (7.2 g) which was directly used for the next reaction without purification.

References:

WO2008/83346,2008,A1 Location in patent:Page/Page column 171