ChemicalBook CAS DataBase List o-Phenanthroline

o-Phenanthroline synthesis

7synthesis methods

Product Name:o-Phenanthroline
CAS Number:66-71-7
Molecular formula:C12H8N2
Molecular Weight:180.21

1,10-Phenanthroline is prepared by heating o-phenylenediamine, glycerin, nitrobenzene and concentrated sulfuric acid.

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3054-95-3 Synthesis

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Yield:66-71-7 80.6%

Reaction Conditions:

with succinic acid;trimethyl-(2-hydroxyethyl)ammonium chloride in N,N-dimethyl-formamide at 75; for 2 h;Reagent/catalyst;Temperature;

Steps:

1-4; 9 Example 1:

First, choline chloride and succinic acid were weighed into a mortar according to the molar ratio of 1:1, simply ground and added to a round-bottomed flask. [Succinic acid] a deep eutectic solvent, dried in a vacuum oven at 60 °C for 140 min before use.Later, in a 100ml three-necked round-bottomed flask, add 10ml N,N-dimethylformamide 10ml, 0.1442g (1mmol) 8-aminoquinoline and [Chlorochloride which accounts for 6% of the mass of 8-aminoquinoline] Alkali][succinic acid] deep eutectic solvent, add 0.138ml (1.2mmol) acrolein diethyl acetal at 75, after reaction for 2h, take the product in the bottle for detection and analysis, the analysis result is: 8- The conversion of aminoquinoline was 88.3%, and the selectivity and yield of 1,10-phenanthroline were 91.3% and 80.6%, respectively.

References:

CN114736129,2022,A Location in patent:Paragraph 0038-0045; 0054; 0055

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