ChemicalBook CAS DataBase List NOBILETIN

NOBILETIN synthesis

14synthesis methods

Product Name:NOBILETIN
CAS Number:478-01-3
Molecular formula:C21H22O8
Molecular Weight:402.39

634-36-6
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478-01-3
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$9.00/1mg

Yield:-

Steps:

Multi-step reaction with 11 steps
1.1: titanium tetrachloride / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: selenium(IV) oxide; dihydrogen peroxide / tert-butyl alcohol / 1.5 h / 50 °C
3.1: triethylamine / methanol / 0 - 20 °C
4.1: potassium carbonate / acetone / 0 - 20 °C / Inert atmosphere
5.1: trichlorophosphate / 0.33 h / 20 °C
5.2: 6 h / 60 °C
6.1: selenium(IV) oxide; dihydrogen peroxide / tert-butyl alcohol / 2.5 h / 50 °C
7.1: triethylamine / methanol / 0 - 20 °C
8.1: potassium carbonate / acetone / 36 h / 20 °C / Inert atmosphere
9.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C
10.1: lithium hexamethyldisilazane / tetrahydrofuran / -30 - 0 °C / Inert atmosphere
11.1: trifluoroacetic acid / methanol / 24 h / 50 °C

References:

Asakawa, Tomohiro;Hiza, Aiki;Nakayama, Miho;Inai, Makoto;Oyama, Dai;Koide, Hiroyuki;Shimizu, Kosuke;Wakimoto, Toshiyuki;Harada, Norihiro;Tsukada, Hideo;Oku, Naoto;Kan, Toshiyuki [Chemical Communications,2011,vol. 47,# 10,p. 2868 - 2870]