Nitrendipine synthesis
- Product Name:Nitrendipine
- CAS Number:39562-70-4
- Molecular formula:C18H20N2O6
- Molecular Weight:360.36
39562-16-8
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Yield:39562-70-4 91.02%
Reaction Conditions:
in ethanol at 65 - 70; for 16 h;Molecular sieve;Large scale;Temperature;
Steps:
1; 1; 3-5
The 2-(3-nitrobenzylidene) ethyl acetoacetate of 150.0kg is added in the ethanol of 480.0kg, the methyl 3-aminocrotonate of 85.0kg is added again, the molecular sieve activation that adds 30.0kg in the system again powder; after the feeding is completed, the temperature is raised to 65-70 °C, and the reaction is carried out for 16 h. After the reaction is completed, the molecular sieve activated powder is filtered out, the filtrate is cooled to 0-10 °C, stirred for 2 h, and the system is centrifuged to obtain a yellow solid and dried at 60-65 °C. In 6 hours, 187.0 kg of nitrendipine (content 99.84%, yield 91.02%). The chromatographic purity of nitrendipine is 99.88%, the impurity B is 0.06%, and the impurity C is 0.03%. The specific chromatographic data are shown in Figure 1.
References:
CN114149360,2022,A Location in patent:Paragraph 0056; 0058-0060; 0065-0070
141-97-9
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99-61-6
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14205-39-1
513 suppliers
$6.00/25g
39562-70-4
381 suppliers
$5.00/50mg
39562-16-8
43 suppliers
inquiry
14205-39-1
513 suppliers
$6.00/25g
39562-70-4
381 suppliers
$5.00/50mg
