Nilotinib genotoxic impurity 3 synthesis
- Product Name:Nilotinib genotoxic impurity 3
- CAS Number:915711-42-1
- Molecular formula:C19H17F3N4O
- Molecular Weight:374.36
1449570-25-5
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915711-42-1
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Yield:915711-42-1 80%
Reaction Conditions:
Stage #1: 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-nitrobenzamide hydrochloridewith tin(ll) chloride in methanol at 10;Reflux;
Stage #2: with sodium hydroxide in methanol;water at 10 - 15; for 2 h;
References:
Amala;Bhujanga Rao;Sreenivas;Dubey [Asian Journal of Chemistry,2013,vol. 25,# 8,p. 4599 - 4602]
1157857-29-8
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915711-42-1
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96-98-0
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$8.00/10g
915711-42-1
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10397-30-5
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$58.20/10ml
915711-42-1
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641571-11-1
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$9.00/1g
915711-42-1
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