Nifuratel synthesis
- Product Name:Nifuratel
- CAS Number:4936-47-4
- Molecular formula:C10H11N3O5S
- Molecular Weight:285.28
Yield:4936-47-4 96.9%
Reaction Conditions:
at 15 - 40; for 5 h;Large scale;Temperature;
Steps:
3.3; 3.4 preparation of a compound represented by the formula E [...]
Heating step 1) made of a compound represented by the formula B N - amino -5 - methylthiomethyl -2 - oxazolidinone reaction liquid, into the step 2) made of a compound represented by the formula D 5 - nitro-furfural reaction solution, to carry out dehydration condensation reaction, the control temperature is 25 °C, after dripping in 15 °C -40 °C reaction under 5h; TLC monitoring, a compound represented by the formula B N - amino -5 - methylthiomethyl -2 - oxazolidinone the reaction is complete the end of the reaction, a compound represented by the refractory fettling [...] E; 4) preparation of a compound represented by the formula E micromolecule The above-mentioned step 3) after the reaction, cooling to room temperature filtration, the filter cake is washed with methanol washing, the centrifugal spin-dry methanol, and then the cake is washed by pure water, until the washing water after PH>6; then methanol pulping for 1 time, drying after drying centrifugally refractory fettling micromolecule a compound represented by the formula E 135.9 kg.
References:
Sichuan Moore Biopharmaceutical Co., Ltd;Cai, zegui;An, feng;He, zhengquan CN104402874, 2016, B Location in patent:Paragraph 0067; 0074; 0075; 0076 ; 0077; 0078