(+)-NICOTINE (+)-DI-P-TOLUOYLTARTRATE SALT synthesis
- Product Name:(+)-NICOTINE (+)-DI-P-TOLUOYLTARTRATE SALT
- CAS Number:68935-27-3
- Molecular formula:C30H32N2O8
- Molecular Weight:548.58
32634-68-7
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22083-74-5
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68935-27-3
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Yield:-
Reaction Conditions:
in ethanol;Reflux;
Steps:
1
A mixture of di-p-toluoyl-d-tartaric acid (23.8 g, 0.0617 mol), 100 ml ethanol, and (R,S)-nicotine (10 g, 0.0617 mol) was stirred for 1 hr, refluxed for 15 min, cooled to room temperature and stirred for 1 hr. The salt was filtered and further recrystallized using ethanol to obtain S-nicotine di-p-toluoyl-d-tartrate (10.5g, 62.1% yield). The salt was further treated as in example I to get (S)-nicotine (3 g, 60 % yield) 87.9 % chiral purity by HPLC.
References:
EP2484673,2012,A2 Location in patent:Page/Page column 6
25162-00-9
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$716.10/50MG
68935-27-3
29 suppliers
$375.00/250mg
68935-25-1
2 suppliers
inquiry