ChemicalBook CAS DataBase List Niclosamide

Niclosamide synthesis

4synthesis methods

Product Name:Niclosamide
CAS Number:50-65-7
Molecular formula:C13H8Cl2N2O4
Molecular Weight:327.12

Niclosamide, 2,5-dichloro-4nitrosaicylanilide (38.1.34), is made by reacting 5-chlorosalicylic acid with 2-chloro-4-nitroaniline in the presence of phosphorus trichloride.

321-14-2 Synthesis

321-14-2
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$15.00/25g

121-87-9 Synthesis

121-87-9
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$41.00/25g

50-65-7
417 suppliers
$14.00/5g

Yield:50-65-7 68.7%

Reaction Conditions:

with phosphorus trichloride in chlorobenzene at 135; for 3 h;Concentration;Solvent;

Steps:

1 Synthesis step 1: preparation N-(2-chloro-4-nitro-phenyl) - 5-chloro-2-hydroxy-benzamide

In 135 °C, to the 5- chlorine salicylic acid (3.44g, 20 . 0mmol) and 2-chloro-4-nitroaniline (3.44g, 20 . 0mmol) dissolved in chlorobenzene mixing solution of adding dropwise PCl₃(2.4g, 17 . 5mmol) dissolved in a chlorobenzene solution. 3 hours later, the reaction solution is cooled to the room temperature. Filtering and collecting the resulting solid, wash, then from ethyl acetate (or acetone) recrystallization to obtain a white solid (6.8g, 68.7%) shaped N-(2-chloro-4-nitro-phenyl) - 5-chloro-2-hydroxy-benzamide.

References:

CN105566147,2016,A Location in patent:Paragraph 0063; 0064; 0065

6626-92-2 Synthesis