N-SUCCINIMIDYL FERROCENECARBOXYLATE synthesis
- Product Name:N-SUCCINIMIDYL FERROCENECARBOXYLATE
- CAS Number:115223-09-1
- Molecular formula:C15H13FeNO410*
- Molecular Weight:327.11
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Yield: 99%
Reaction Conditions:
with dicyclohexyl-carbodiimide in 1,4-dioxane for 12 h;
Steps:
1 Preparation 1
According to the preparation method disclosed in Aanl. Biochem., 218, 436(1994), a mixture of 1,000 mg of ferrocenecarboxylic acid(4.35 mmol) and 560 mg of N-hydroxysuccineimide(4.87 mmol) was dissolved in 40 ml of distilled 1,4-dioxane, added 100 mg of dicyclohexylcarbodiimide dissolved in 10 ml of distilled 1,4-dioxane, and stirred for 12 hours under a nitrogen atmosphere. The resulting solution was filtered and the solid thus obtained was purified by silicagel chromatography using a mixture of n-hexane and ethylacetate(1:1, Rf=0.40) as an eluent to obtain 1.39 g of the title compound as a light yellow solid (Yield: 99%). [00029] 1H NMR(CDCl3; 300 MHz) δ 2.88(4H, br s), 4.39(5H, s), 4.57(2H, m), 495(2H, m) ppm
References:
Mitocon Ltd. US6809201, 2004, B2 Location in patent:Page/Page column 3-4; 5