N-PROPARGYLPHTHALIMIDE synthesis
- Product Name:N-PROPARGYLPHTHALIMIDE
- CAS Number:7223-50-9
- Molecular formula:C11H7NO2
- Molecular Weight:185.18
1074-82-4
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$5.00/25g
106-96-7
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$30.00/25g
7223-50-9
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$40.00/5g
Yield:7223-50-9 98%
Reaction Conditions:
in N,N-dimethyl-formamide at 25; for 16 h;Inert atmosphere;
Steps:
2 - Prop-2-ynylisoindoline-1,3-dione (Intermediate ASN)
A mixture of (1, 3-dioxoisoindolin-2-yl)potassium (3.00 g, 16.2 mmol) and 3-bromoprop-1-yne (2.89 g, 24.3 mmol) in DMF (20 mL) was stirred at 25 °C for 16 hours. On completion, the mixture was diluted in water (80 mL), and a large amount of yellow solid precipitated from the solution. The mixture was filtered and the filter cake was collected and dried in vacuo to afford the title compound (2.94 g, 98% yield) as a light solid. LC-MS (ESI+) m/z 186.0 (M+H)+.
References:
KYMERA THERAPEUTICS, INC.;MAINOLFI, Nello;JI, Nan;KLUGE, Arthur F.;WEISS, Matthew M.;ZHANG, Yi;ZHENG, Xiaozhang WO2020/113233, 2020, A1 Location in patent:Paragraph 00962; 004829
