N-PENTADECANOIC ACID ETHYL ESTER synthesis
- Product Name:N-PENTADECANOIC ACID ETHYL ESTER
- CAS Number:41114-00-5
- Molecular formula:C17H34O2
- Molecular Weight:270.45
29823-18-5
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$9.00/1g
1070-00-4
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$59.10/100ml
41114-00-5
91 suppliers
$32.00/1g
Yield:41114-00-5 54%
Reaction Conditions:
with potassium fluoride;benzylnixantphos;iron(II) acetate in tetrahydrofuran at 40; for 8 h;Inert atmosphere;Negishi Coupling;
Steps:
Typical procedure; Synthesis of tetradecylbenzene (3a)
General procedure: A THF solution of trioctylaluminum (4.50 mL, 1.00 M, 4.5 mmol) was added to a mixture of Fe(OAc)2 (26.4 mg, 0.15 mmol), Bn-Nixantphos (193 mg, 0.30 mmol), KF (262 mg, 4.5 mmol) and (6-bromohexyl)benzene (732 mg, 3.1 mmol) in THF (1.50 mL) at 0 °C. The mixture was stirred at 40 °C for 12 h. An aqueous solution of HCl (3N) was added to the reaction mixture at 0 C. The aqueous layer was extracted with ethyl acetate four times. The combined organic layer was filtered through a pad of Florisil. After removal of the solvent, the crude product was purified by column chromatography (silica gel, hexane, Rf = 0.86) and recycling GPC (toluene) to afford the titled compound (415 mg, 50%) as a colorless oil;
References:
Agata, Ryosuke;Kawamura, Shintaro;Isozaki, Katsuhiro;Nakamura, Masaharu [Chemistry Letters,2019,vol. 48,# 3,p. 238 - 241] Location in patent:supporting information
4292-19-7
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140-88-5
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$12.00/100ml
41114-00-5
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$32.00/1g
64-17-5
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$10.00/50g
1002-84-2
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$17.00/5g
41114-00-5
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$32.00/1g
112-71-0
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$5.00/10g
41114-00-5
91 suppliers
$32.00/1g
64-17-5
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$10.00/50g
18300-91-9
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$62.00/5g
41114-00-5
91 suppliers
$32.00/1g