ChemicalBook CAS DataBase List N,N-Dimethyl-2-(p-tolyloxy)ethanamine

N,N-Dimethyl-2-(p-tolyloxy)ethanamine synthesis

4synthesis methods

Product Name:N,N-Dimethyl-2-(p-tolyloxy)ethanamine
CAS Number:51344-14-0
Molecular formula:C11H17NO
Molecular Weight:179.26

106-44-5 Synthesis

106-44-5
476 suppliers
$14.00/5g

2-Dimethylaminoethyl chloride hydrochloride

4584-46-7
5 suppliers
$21.69/100g

51344-14-0
32 suppliers
$13.00/100mg

Yield:51344-14-0 91%

Reaction Conditions:

with triethylamine;potassium hydroxide in di-isopropyl ether;N,N-dimethyl-formamide at 80; for 2 h;Reagent/catalyst;

Steps:

2 Example 1 Preparation of 4- [2- (dimethylamino) ethoxy] toluene

108 g (1 mol) of p-hydroxytoluene, 61.7 g (1.1 mol) of potassium hydroxide, 200 mL of DMF and 200 mL of isopropyl ether(1.1 mol) of (2- (dimethylamino) chloroethane hydrochloride) was added to 250 ppm of DMF, and 110 g of triethylamineAnd the mixture was stirred at 80 ° C for 2 h. After the reaction was completed, the insoluble matter was removed by filtration, and the filtrate was decompressed to recover most of the solvent.2 mol·L-1 sulfuric acid to pH to 2, 500 mL of chloroform to extract twice, ice water cooling with sodium hydroxide solution (w = 20%)The aqueous phase was neutralized to pH 10 and extracted with 500 mL of ethyl acetate, dried over anhydrous sodium sulfate, and the ethyl acetate was recovered under reduced pressure.Distillation of the title compound gave 162.8 g of a colorless oil in 91% yield.

References:

CN106748862,2017,A Location in patent:Paragraph 0037; 0053; 0054; 0055; 0056