N-methyl-o-toluidine hydrochloride synthesis
- Product Name:N-methyl-o-toluidine hydrochloride
- CAS Number:10541-29-4
- Molecular formula:C8H12ClN
- Molecular Weight:157.6406
Yield:10541-29-4 91%
Reaction Conditions:
Stage #1: methanol;o-toluidinewith [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II);potassium tert-butylate at 150; for 8 h;Inert atmosphere;Autoclave;
Stage #2: with hydrogenchloride in methanol;water;
References:
Ogata, Osamu;Nara, Hideki;Fujiwhara, Mitsuhiko;Matsumura, Kazuhiko;Kayaki, Yoshihito [Organic Letters,2018,vol. 20,# 13,p. 3866 - 3870] Location in patent:supporting information
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