ChemicalBook CAS DataBase List N-METHOXY-N-METHYLTRIFLUOROACETAMIDE

N-METHOXY-N-METHYLTRIFLUOROACETAMIDE synthesis

5synthesis methods

Product Name:N-METHOXY-N-METHYLTRIFLUOROACETAMIDE
CAS Number:104863-67-4
Molecular formula:C4H6F3NO2
Molecular Weight:157.09

6638-79-5 Synthesis

6638-79-5
575 suppliers
$6.00/25g

407-25-0 Synthesis

407-25-0
455 suppliers
$9.00/1g

104863-67-4
148 suppliers
$5.00/250mg

Yield:104863-67-4 95%

Reaction Conditions:

with pyridine in dichloromethane at 0; for 1 h;Large scale;

Steps:

General procedure

To a suspension of N,O-dimethyl-hydroxylamine hydrochloride (107.2 Kg, 1.1 kmol) in dichloromethane (400 L) were added trifluoroacetic anhydride (210 Kg, 1 kmol) and pyridine (174 Kg, 2.2 kmol) sequentially at0 °C. The mixture was stirred at 0°C for 1 h and then diluted with ice water (300 L) and washed with 2 M HCl (300 L). The aqueous solution was extracted twice with dichloromethane and dried under MgSO4. The crude Weinreb amide was obtained after concentration without further purification (90 %purity, 95 % yield).

References:

Jiang;Cheng;Yuan [Asian Journal of Chemistry,2015,vol. 27,# 7,p. 2406 - 2408]

6638-79-5 Synthesis

6638-79-5
575 suppliers
$6.00/25g

104863-67-4
148 suppliers
$5.00/250mg

References

6638-79-5 Synthesis

6638-79-5
575 suppliers
$6.00/25g

76-05-1 Synthesis