Yield: 97%

Reaction Conditions:

with triethylamine in dichloromethane at 10 - 20;

Steps:

1.1
[0238] Step 1: 3-Trifluoromethylaniline (3 g, 0.0186 mol) was dissolved in dichloromethane (50 mL) and triethylamine (2.07 g, 0.0205 mol) was added. The reaction mixture was cooled to <10°C and chloroacetyl chloride (2.31 g, 0.0205 mol) was added, keeping the temperature below 10°C. After stirring for 2 hours at room temperature, saturated sodium bicarbonate solution was added and the mixture was shaken and separated. The organic layer was dried over magnesium sulfate, filtered and evaporated to give 2-chloro-N-(3- txifluoromethylphenyl)acetarnide which was used without further purification. Yield = approximately 97%.O

References:

DESIGNMEDIX, INC.;STATE OF OREGON, ACTING BY AND THROUGH THE STATE BOARD Of HIGHER EDUCATION ON BEHALF OF PORTLAND STATE UNIVERSITY;PEYTON, David, H.;BURGESS, Steven, J. WO2011/34971, 2011, A1 Location in patent:Page/Page column 30-31