ChemicalBook CAS DataBase List N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID synthesis

10synthesis methods

Product Name:N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
CAS Number:102507-13-1
Molecular formula:C10H19NO5
Molecular Weight:233.26

182958-73-2 Synthesis

Carbamic acid, [2-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-, 1,1-

182958-73-2
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N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

102507-13-1
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$43.00/100mg

Yield:102507-13-1 76%

Reaction Conditions:

with sodium dihydrogenphosphate in tetrahydrofuran at 0; for 4 h;

Steps:

1.2 Step 2: Preparation of (s)-2-tert-butoxyamido-3-methyl-3-hydroxybutyric acid
(s)-2-tert-butoxyamido-3-methyl-3-hydroxybutanol (20 g) was added to THF (50 mL). After adding saturated sodium dihydrogen phosphate solution (50 mL), the reaction was cooled to 0°C. Add bleach (6%, 350 mL) slowly. After 4 hours of reaction, slowly rise to room temperature. After TLC detects that the reaction is complete, it is quenched by adding sodium thiosulfate. Rotary evaporation to remove THF, then add dichloromethane (100mLX4) for extraction, dry and filter, concentrate to the crude reaction product, add n-hexane (100mL), beating and filtering to obtain pure product (s)-2-tert-butoxyamide -3-Methyl-3-hydroxybutyric acid (16 g, 76%).

References:

Zhejiang Kaipu Chemical Co., Ltd.;Luo Linfeng;Tan Xianghui;Yan Xiaodong;Shen Yipeng;Zhou Chen CN111909067, 2020, A Location in patent:Paragraph 0023-0025; 0028-0029

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