ChemicalBook CAS DataBase List N-BIOTINYL-3,6,9-TRIOXAUNDECANE-1,11-DIAMINE

N-BIOTINYL-3,6,9-TRIOXAUNDECANE-1,11-DIAMINE synthesis

13synthesis methods

Product Name:N-BIOTINYL-3,6,9-TRIOXAUNDECANE-1,11-DIAMINE
CAS Number:359860-27-8
Molecular formula:C18H34N4O5S
Molecular Weight:418.55

929-75-9
155 suppliers
$34.00/250mg

35013-72-0 Synthesis

35013-72-0
357 suppliers
$12.00/100mg

N-BIOTINYL-3,6,9-TRIOXAUNDECANE-1,11-DIAMINE

359860-27-8
124 suppliers
$80.00/2.5mg

Yield:359860-27-8 98%

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide at 20; for 12 h;

Steps:

19 Synthesis of a Bifunctional Linkers
Compound 7. N,N-dimethylformamide (400 μL), Biotin NHS (72 mg, 0.211 mmol), and N,N-diisopropylethylamine (33 mg, 0.25 mmol) were added to 15 (42 mg, 0.19 mmol) for 12 h at RT. The reaction was concentrated under reduced pressure and purified on silica gel using flash chromatography (2-5% methanol in CH₂Cl₂) to afford the product as an oil (84 mg, 0.189 mmol, 98% yield).

References:

The Regents of the University of California;Esko, Jeffrey D.;Tor, Yitzhak US9889182, 2018, B2 Location in patent:Page/Page column 93; 95; 96; 97; 98

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101187-40-0 Synthesis