ChemicalBook CAS DataBase List N-Acetylcysteine amide

N-Acetylcysteine amide synthesis

6synthesis methods

Product Name:N-Acetylcysteine amide
CAS Number:38520-57-9
Molecular formula:C5H10N2O2S
Molecular Weight:162.21

N-Acetyl-L-cysteine methyl ester (10 g) under a flush of nitrogen was treated with ammonium hydroxide (28% aqueous, 66 mL) over 10 minutes at room temperature and stirred for 6 hours. The resulting solution was concentrated in vacuo and ethanol (100 mL) was added. Then the solution was concentrated again under reduced pressure at 48 00 then subjected to high vacuum overnight to afford N-acetylcysteine amide as a white crystalline solid.
N-Acetyl-L-cysteinamide

7652-46-2 Synthesis

7652-46-2
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$40.00/250mg

38520-57-9
101 suppliers
$60.00/1mg

Yield:38520-57-9 93%

Reaction Conditions:

with ammonium hydroxide in water at 20; for 168 h;

Steps:

(R)-2-Acetylamino-3-merca to-propionamide (\2) (used during synthesis of 4)

(R)-2-Acetylamino-3-merca to-propionamide (2) (used during synthesis of 4) (R)-2-Acetylamino-3-mercapto-propionic acid methyl ester (177 mg, 1.0 mmol) was dissolved in NH4OH (28% aq., 5ml_) and the reaction mixture stirred at rt for 7 days. The solvent was evaporated in vacuo to give a white solid (150mg, 0.93 mmol, 93%).

References:

WO2015/181551,2015,A1 Location in patent:Page/Page column 35