N-[(4-Nitrophenyl)sulfonyl]glycine synthesis
- Product Name:N-[(4-Nitrophenyl)sulfonyl]glycine
- CAS Number:15054-44-1
- Molecular formula:C8H8N2O6S
- Molecular Weight:260.22
Yield:15054-44-1 94.59%
Reaction Conditions:
with sodium carbonate in water; for 5 h;
Steps:
2.2 General procedure for the synthesis of substituted benzenesulphonamoyl alkanamides (3a-p)
General procedure: Sodium carbonate (Na2CO3, 1.590g, 15mmol) was added to a solution of amino acids (2a-h, 12.5mmol) in water (15mL) with continuous stirring until all the solutes had dissolved. The solution was cooled to-5°C and the appropriate benzenesulphonyl chloride (1a-c, 15mmol) was added in four portions over a period of 1h. The slurry was further stirred at room temperature for about 4h. The progress of the reaction was monitored using TLC (MeOH/DCM, 1:9). Upon completion, the mixture was acidified using 20% aqueous hydrochloric acid to pH 2. The crystals was filtered via suction and washed with pH 2.2 buffer. The pure products (3a-x) were dried over self-indicating fused silica gel in a desiccator.
References:
Ugwu;Okoro;Ukoha;Okafor;Ibezim;Kumar [European Journal of Medicinal Chemistry,2017,vol. 135,p. 349 - 369]
