ChemicalBook CAS DataBase List N-(3-Aminopropyl)morpholine

N-(3-Aminopropyl)morpholine synthesis

10synthesis methods

Product Name:N-(3-Aminopropyl)morpholine
CAS Number:123-00-2
Molecular formula:C7H16N2O
Molecular Weight:144.21

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123-00-2
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Yield:123-00-2 86%

Reaction Conditions:

with hydrazine hydrate in ethanol for 24 h;Reflux;

Steps:

4.1.13.1. General procedures for the preparation of compounds 7b-f and 7h-l
General procedure: To a solution of compounds 6b-l (9.15 mmol) in 30 mLEtOH was added hydrazine monohydrate (36.6 mmol; 4 eq.) andthe mixture was vigorously stirred under reflux for 24 h. The whitesolid was filtered off and washed with EtOH. Filtrate was concentratedunder vacuum to dryness and taken up with EtOAc. The solidresidue was filtered again and filtrate was concentrated in vacuo toafford the desired products 7b-7l. NH2 signals are missing for allcompounds in 1H NMR spectra.

References:

Tazarki, Helmi;Zeinyeh, Wael;Esvan, Yannick J.;Knapp, Stefan;Chatterjee, Deep;Schr?der, Martin;Joerger, Andreas C.;Khiari, Jameleddine;Josselin, Béatrice;Baratte, Blandine;Bach, Stéphane;Ruchaud, Sandrine;Anizon, Fabrice;Giraud, Francis;Moreau, Pascale [European Journal of Medicinal Chemistry,2019,vol. 166,p. 304 - 317]

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