mPEG8-Alkyne synthesis
- Product Name:mPEG8-Alkyne
- CAS Number:880081-81-2
- Molecular formula:C20H38O9
- Molecular Weight:422.51
25990-96-9
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Yield:880081-81-2 96%
Reaction Conditions:
Stage #1: 2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanolwith sodium hydride in tetrahydrofuran at 0 - 5; for 0.0833333 h;
Stage #2: propargyl bromide in tetrahydrofuran at 0 - 5; for 1 h;
Steps:
261a Intermediate 261a
Into a 500-mL round-bottom flask, was placed a solution of 2-(2-(2-(2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanol (15 g, 39.06 mmol, 1.00 equiv) in tetrahydrofuran (150 mL).
This was followed by the addition of sodium hydride (1.9 g, 79.17 mmol, 1.01 equiv), in portions at 0-5° C. in 5 min.
To this was added a solution of 3-bromoprop-1-yne (9.3 g, 78.81 mmol, 2.02 equiv) in toluene (20 mL) dropwise with stirring at 0-5° C. in 5 min.
The resulting solution was stirred for 1 h at 0-5° C. in a water/ice bath.
The reaction progress was monitored by LCMS/TLC (ethyl acetate/petroleum ether=1:1).
The solids were filtered out.
The resulting mixture was concentrated under vacuum.
This resulted in 15.9 g (96%) of 3-(2-(2-(2-(2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)prop-1-yne as brown oil
References:
US9301951,2016,B2 Location in patent:Page/Page column 494