morpholine-4-carboximidamide synthesis
- Product Name:morpholine-4-carboximidamide
- CAS Number:5638-78-8
- Molecular formula:C5H11N3O
- Molecular Weight:129
110-91-8
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5638-78-8
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Yield: 75%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in acetonitrile at 20; for 12 h;
Steps:
General procedure.
General procedure: Subsituted guanidines were prepared according to the literatureprocedure.1 To a stirred solution of 1H-pyrazole-1-carboxamidine hydrochloride (1.00 g; 6.8mmol; 1.00 equiv.) and DIPEA (1.24 mL; 7.2 mmol; 1.05 equiv.) in MeCN (25 mL),benzylamine (782 μL; 7.2 mmol; 1.05 equiv.) was added. The reaction mixture was stirred atambient temperature overnight and precipitated solid filtered and washed with MeCN andEt2O to obtain pure product 4c as an off-white solid.
References:
Solomin, Vitalii V.;Seins, Alberts;Jirgensons, Aigars [Synlett,2020,vol. 31,# 15,p. 1507 - 1510] Location in patent:supporting information
1568908-87-1
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5638-78-8
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110-91-8
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867-44-7
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5638-78-8
52 suppliers
$41.00/100mg