ChemicalBook CAS DataBase List MK-4827 (tosylate)

MK-4827 (tosylate) synthesis

11synthesis methods

Product Name:MK-4827 (tosylate)
CAS Number:1038915-73-9
Molecular formula:C26H28N4O4S
Molecular Weight:492.5899

1038915-60-4 Synthesis

1038915-60-4
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104-15-4
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1038915-73-9
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Yield:1038915-73-9 110 g

Reaction Conditions:

in water at 20 - 30; for 4 h;Inert atmosphere;

Steps:

3 Method for synthesizing 2-[4-((3S)-3-piperidinyl)phenyl]-2H-indazole-7-carboxamide p-toluenesulfonic acid salt salt crystal form A
100 g of 2-[4-((3S)-3-piperidinyl)phenyl]-2H-indazole-7-formyl was added to the reaction flask. 750mL of ethanol,Water 250mL temperature control to 20 ° C - 30 ° C,Slowly add 50% (mass fraction) of p-toluenesulfonic acid (75g) monohydrate under nitrogen protection Solution,After the addition, the mixture was stirred at a temperature of 20 ° C for 4 hours, filtered and washed with water, and dried under vacuum at 40 ° C to obtain crystal form A 110 g.

References:

Guangzhou Keruite Biological Technology Co., Ltd.;Wang Yong;Yu Jinquan CN108530425, 2018, A Location in patent:Paragraph 0062-0064