METHYL2-CHLORO-5-FLUORONICOTINATE synthesis
- Product Name:METHYL2-CHLORO-5-FLUORONICOTINATE
- CAS Number:847729-27-5
- Molecular formula:C7H5ClFNO2
- Molecular Weight:189.57
38186-88-8
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18107-18-1
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$33.00/5g
847729-27-5
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$12.00/100mg
Yield:847729-27-5 72%
Reaction Conditions:
in methanol;hexane;dichloromethane at 0; for 1 h;
Steps:
58.1
EXAMPLE 58 4- ( (F 5-FLUORO-2- (4-FLUOROBENZYL) PYRIDIN-3- YL1CARBONYL} AMINO) METHYL1BENZOIC ACID STEP 1. Methyl 5-FLUORO-2- (4-FLUOROBENZYL) nicotinate; 2-Chloro-5-fluoronicotinic acid (1.00 g, 5.70 mmol) was treated with 2 M solution of (Trimethylsilyl) DIAZOMETHANE in hexane (5.70 mL, 11.4 mmol), methanol (4 mL), and dichloromethane (14 mL) at 0 °C for 1 h. The mixture was quenched with acetic acid and concentrated under reduced pressure. The residue was purified by flush column chromatography on silica gel eluting with hexane/ethyl acetate (10/1) to afford 0.78 g (72%) of the title compounds as colorless oil : IH-NMR (CDC13) 6 8.41 (1H, d, J = 3. 1 HZ), 7.93 (1H, dd, J = 7. 6,3. 1 HZ), 3.98 (3H, s).
References:
PFIZER INC.;PFIZER JAPAN, INC. WO2005/21508, 2005, A1 Location in patent:Page/Page column 97
38186-88-8
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$6.00/1g
74-88-4
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847729-27-5
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$12.00/100mg
67-56-1
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$7.29/5ml-f
38186-88-8
237 suppliers
$6.00/1g
847729-27-5
85 suppliers
$12.00/100mg