ChemicalBook CAS DataBase List Methyl chlorosulfonate

Methyl chlorosulfonate synthesis

14synthesis methods

Product Name:Methyl chlorosulfonate
CAS Number:812-01-1
Molecular formula:CH3ClO3S
Molecular Weight:130.55

67-56-1 Synthesis

67-56-1
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$7.29/5ml-f

812-01-1
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$168.00/250 mg

Yield:812-01-1 41%

Reaction Conditions:

with sulfuryl dichloride at 0 - 20; for 2.5 h;Inert atmosphere;

Steps:

Methyl chlorosulfate preparation
An equimolar amount of dry methanol (5 mL, 0.12 mol) was slowly added over 30 min to sulfuryl chloride (10 mL, 0.12 mol) under argon at 0 °C. After complete addition, the mixture was allowed to stir for 2 h at room temperature with a continuous argon flux to remove hydrogen chloride. The resulting liquid was distilled (b.p.=54-55 °C, 30 Torr; lit: 48.1 °C, 29 Torr) affording the title compound (6.7 g, 41% yield).

References:

Silva, Saúl;Maycock, Christopher D. [Tetrahedron Letters,2018,vol. 59,# 13,p. 1233 - 1238] Location in patent:supporting information

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