ChemicalBook CAS DataBase List METHYL BIPHENYL-2-CARBOXYLATE

METHYL BIPHENYL-2-CARBOXYLATE synthesis

14synthesis methods

Product Name:METHYL BIPHENYL-2-CARBOXYLATE
CAS Number:16605-99-5
Molecular formula:C14H12O2
Molecular Weight:212.25

610-97-9 Synthesis

610-97-9
406 suppliers
$9.00/1g

100-63-0 Synthesis

100-63-0
362 suppliers
$10.00/1g

16605-99-5
38 suppliers
$45.00/20mg

Yield: 85%

Reaction Conditions:

with potassium carbonate in acetonitrile at 50; for 8 h;

Steps:

5.0 Exact experimental procedure for the synthesis of 4-methyl-1,1'-biphenyl (3c)
General procedure: The acetonitrile (3 mL) were added in to the oven dried 25mL R.B.F containing compound 1a (54.07mg, 0.5 mmol), followed by addition of K₂CO₃ (152.02 mg, 2.2 equiv), catalyst (2.39 mg, 2 mol% 44.48w/v), compound 2c (0.55 mmol, 119.91 mg, 1.1 equiv). The reaction mixture was stirred at 50 °C for 16 h, after complete conversion of starting material (indicated by TLC), the solvent was evaporated by rotary evaporator and crude compound was purified by column chromatography (eluent: 2% EA/Hexane) to get the compound 4-methyl-1,1'-biphenyl (3c, 73.08 mg, 87%).

References:

Hegde, Rajeev V.;Ghosh, Arnab;Patil, Siddappa A.;Dateer, Ramesh B. [Tetrahedron,2019,vol. 75,# 52,art. no. 130777] Location in patent:supporting information

610-94-6 Synthesis