ChemicalBook CAS DataBase List METHYL 5-NITROSALICYLATE

METHYL 5-NITROSALICYLATE synthesis

5synthesis methods

Product Name:METHYL 5-NITROSALICYLATE
CAS Number:17302-46-4
Molecular formula:C8H7NO5
Molecular Weight:197.14

96-97-9 Synthesis

96-97-9
362 suppliers
$14.14/1gm:

74-88-4
349 suppliers
$15.00/10g

17302-46-4
152 suppliers
$6.00/1g

Yield: 77%

Reaction Conditions:

with potassium carbonate

Steps:

7.3.462 7.3.462 N2,N4-Bis(4-methoxy-3-methoxycarbonylphenyl)-5-fluoro-2,4-pyrimidinediamine (R945066)
In a manner analogous to the preparation of N2,N4-bis(3-methoxy-4-methoxycarbonyl)phenyl)-5-fluoro-2,4-pyrimidinediamine, 2-hydroxy-5-nitrobenzoic acid (1 g, 5.5 mmol), potassium carbonate (3 g, 22 mmol) and iodomethane (1 mL, 16 mmol) gave methyl 2-hydroxy-5-nitrobenzoate (880 mg, 77%).

References:

RIGEL PHARMACEUTICALS, INC.;Singh, Rajinder;Argade, Ankush;Payan, Donald;Molineaux, Susan;Holland, Sacha;Clough, Jeffrey;Keim, Holger;Bhamidipati, Somasekhar;Sylvain, Catherine;Li, Hui;Rossi, Alexander US2015/266828, 2015, A1 Location in patent:Paragraph 1025

119-36-8 Synthesis