Methyl 4-bromo-2,6-dichlorobenzoate synthesis
- Product Name:Methyl 4-bromo-2,6-dichlorobenzoate
- CAS Number:232275-53-5
- Molecular formula:C8H5BrCl2O2
- Molecular Weight:283.93
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Yield: 98.1%
Reaction Conditions:
with potassium carbonate in acetonitrile at 20; for 16 h;
Steps:
4 methyl 4-bromo-2,6-dichlorobenzoate (248-1)
General procedure: To a 100 mL 1-neck round bottom flask, the mixture of 4-bromo-2,6-dichloro-benzoic acid (500 mg, 1.85 mmol), iodomethane (788.82 mg, 5.56 mmol, 345.97 uL), Potassium carbonate (1.28 g, 9.26 mmol, 559.01 uL) in acetonitrile (20 mL) was stirred at RT for 6 h, then it was diluted with water, extracted with EA, dried with Na2SO4, concentrated to afford methyl 4-bromo-2,6-dichloro-benzoate (516 mg, 1.82 mmol, 98.10% yield) as yellow oil, it was used to next step without further purification. 1H NMR (400 MHz, CDCl3) δ 7.51 (s, 2H), 3.97 (s, 3H).
References:
The Regents of the University of California;Shanghai ChemPartner Co., Ltd. US2021/171455, 2021, A1 Location in patent:Paragraph 0759; 0915-0917; 0927-0929; 0977-0979
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