ChemicalBook CAS DataBase List methyl 3-chloro-4-hydroxyphenylacetate

methyl 3-chloro-4-hydroxyphenylacetate synthesis

7synthesis methods

Product Name:methyl 3-chloro-4-hydroxyphenylacetate
CAS Number:57017-95-5
Molecular formula:C9H9ClO3
Molecular Weight:200.62

33697-81-3 Synthesis

33697-81-3
165 suppliers
$19.07/5g

57017-95-5
55 suppliers
$70.00/500mg

Yield:57017-95-5 100%

Reaction Conditions:

with sulfuric acid in methanol at 68; for 15 h;

Steps:

14.a a-[3-chloro-4-hydroxy-phenyl]-methyl acetate
1 ml of sulfuric acid is added to a solution of 10 g (53.6 mmol) of (3-chloro-4-hydroxy-phenyl)-acetic acid in 100 ml of methanol. The reaction mixture is stirred at 68° C. for 15 hours and then concentrated under vacuum. After adding 100 ml of water and 100 ml of ethyl acetate, the reaction mixture is extracted with ethyl acetate. The organic phases are combined, washed with saturated sodium chloride solution and then dried over magnesium sulfate, filtered, and evaporated. 11 g (100%) of (3-chloro-4-hydroxy-phenyl)-methyl acetate is obtained in the form of a light yellow oil.

References:

GALDERMA RESEARCH & DEVELOPMENT US2010/144884, 2010, A1 Location in patent:Page/Page column 17

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67-56-1 Synthesis