METHYL 3,5-DIHYDROXY-4-METHYLBENZOATE synthesis

5synthesis methods

Product Name:METHYL 3,5-DIHYDROXY-4-METHYLBENZOATE
CAS Number:75238-29-8
Molecular formula:C9H10O4
Molecular Weight:182.17

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Yield:75238-29-8 96.8%

Reaction Conditions:

with sulfuric acid;potassium carbonate in methanol at 60;

Steps:

A11.1 Step 1: Methyl 3,5-dihydroxy-4-methylbenzoate

A mixture solution of 3,5-dihydroxy-4-methylbenzoic acid (4.7 g, 27.9 mmol) and H2504 (1.0 mL) in methanol (50 mL) was stirred at 60 °C for overnight. Then the mixture solution was concentrated and the residue was dissolved in EA (100 mL), washed with saturated NaHCO3 solution (100 mL x 3), dried over Na2504, filtered and concentrated to give the product (4.93 g, 96.8%). MS (ESI, m/e) [M+1] 183.1.

References:

WO2019/34009,2019,A1 Location in patent:Paragraph 0134-0136

67-56-1 Synthesis