成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List METHYL 3,4-DIFLUOROBENZOATE
369-25-5

METHYL 3,4-DIFLUOROBENZOATE synthesis

9synthesis methods
-

Yield: 84%

Reaction Conditions:

with thionyl chloride at 15; for 16 h;Inert atmosphere;

Steps:

106 Example 106: Synthesis of methyl 3,4-difluorobenzoate (127)
To a mixture of compound 126 (20.0 g, 127 mmol) in MeOH (200 mL) was added dropwise SOCl2 (46.0 g, 380 mmol). Then the reaction was stirred at 15° C. for 16 h. The mixture was concentrated under reduced pressure. The residue was diluted with EA (200 mL), washed with sat. NaHCO3 (2×50 mL), the organic layer was dried over Na2SO4, concentrated under reduced pressure and dried in vacuum to give compound 127 as white solid (18.3 g, 84% yield, 99% purity). 1H NMR (400 MHz, CDCl3) δ 7.88-7.82 (2H, m), 7.27-7.22 (1H, m), 3.93 (3H, s).

References:

THERAVANCE BIOPHARMA R&D IP, LLC;Kulyk, Svitlana;Owens, Christina;Sullivan, Steven D.E.;Kozak, Jennifer;Hughes, Adam D. US2020/188370, 2020, A1 Location in patent:Paragraph 0479; 0738; 0739

METHYL 3,4-DIFLUOROBENZOATE Related Search: